June 16, 2021
3 min. read

10 Early Symptoms of Lupus, According To a Pharmacist


Lupus is a long-term autoimmune disease in which the body’s immune system attacks healthy cells. Those living with lupus may experience a wide range of symptoms, because lupus affects the whole body and can attack virtually any part of it, including skin, major organs, hair, muscles, joints, and the digestive system.

That being said, common lupus symptoms include inflammation, swelling, and damage to the joints, skin, kidneys, blood, heart, and lungs. While there is no cure for lupus, early treatment can help to keep symptoms under control in order to help a person manage their symptoms and prevent serious complications.

lupus infographic

Below are ten early signs of lupus, and how to identify them:

Hair Loss

Hair loss is often the first sign of lupus for many patients, as it is the result of inflammation of the skin and scalp. As a result of lupus treatment, many patients will experience renewed hair growth. However, if you develop lesions on your scalp, there is a risk of your hair loss becoming permanent.


Ninety percent of people with lupus will experience general fatigue at some point during the course of their disease. While some patients find that napping during the day helps, you will want to speak with your doctor if you’re living with debilitating fatigue.

lupus symptoms

Unexplained Fever

An early symptom of lupus includes a low-grade fever without cause. These fevers are usually intermittent, with temperature hovering between 98.5˚F (36.9˚C) and 101˚F (38.3˚C). Because a low-grade fever could be a symptom of inflammation, infection, or imminent flare-up, you should see a doctor if you are experiencing them recurrently.

Malar Rash

About half of all lupus patients experience a characteristic rash called the malar or “butterfly rash. This rash is so-named because it spans the width of the face and covers both the cheeks and the bridge of the nose. This rash will be red, elevated, oftentimes scaly, and can appear either after exposure to the sun or spontaneously. In addition to its placement, a malar rash can be distinguished from other rashes because it spares the nasal folds, which are the spaces just under each side of your nose.

patient provider

Pulmonary Issues

Inflammation of the lungs, diaphragm, and pulmonary blood vessels can be another possible symptom of lupus. A patient will experience these symptoms as chest pain upon inhalation, though over time they can shrink one's lung size and cause both ongoing chest pain and shortness of breath.

Kidney Inflammation

Nephritis, or inflammation of the kidneys, is another early sign of lupus. This inflammation can make it harder for the kidneys to filter toxins and wastes from the blood. Since early symptoms of nephritis can go unnoticed, monitoring of kidney function is recommended after a lupus diagnosis. If left untreated, lupus nephritis can lead to end-stage renal disease (ESRD).

Painful & Swollen Joints

The inflammation associated with lupus can also affect the joints, causing intermittent pain, stiffness, and visible swelling, particularly in the morning. While mild at first, this pain can gradually become more intense over time.

lupus pain

Gastrointestinal Problems

Some patients, though not all, may experience occasional heartburn, acid reflux, or other gastrointestinal problems as a result of the inflammation of the digestive tract.

Thyroid Problems

For people with lupus, it’s not uncommon to develop autoimmune thyroid disease. A healthy thyroid is responsible for helping control your body’s metabolism. However, a poorly functioning thyroid can affect vital organs like your brain, heart, kidneys, and liver, and can also result in weight gain or weight loss, as well as dry skin and hair and moodiness.

Dry Mouth and Eyes

Some patients living with lupus will also develop something called Sjogren’s disease, which is another autoimmune disorder. Sjogren’s causes the glands responsible for tears and saliva to malfunction, resulting in both dry mouth and eyes. In some cases, women with lupus and Sjogren’s may also experience dryness of the vagina and skin.

Because lupus causes swelling and inflammation throughout the body, the list of symptoms is long. However, it’s important to remember that not all patients will experience every symptom, and also that symptoms can disappear or come and go over time.

Resources: Medical News Today Medical News Today Versus Arthritis John Hopkins Lupus Center

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